Ductwork for Clean Rooms (ISO 14644): Comprehensive Solution for Particle Control, Pressure Management, and Compliance

Clean rooms require ultra-controlled air: low particle concentrations, stable differential pressures, and airtightness throughout the entire distribution system. At GG123 Mexico, we integrate BIM modeling, automated machinery, and validation protocols to deliver a ductwork solution ready to meet ISO 14644 and regulatory standards for healthcare, food, pharmaceutical, and microelectronics sectors.

The technical and business problem we solve

Contamination and cleaning

Duct geometry, material, and sealing directly impact particle retention, ease of cleaning, and risk of cross-contamination. Critical zones (ISO 5–7) demand smooth surfaces and airtight joints.

Stable differential pressure

Pressure cascades between rooms (positive/negative) require airtight ducts, precise dampers, and control systems to protect high-demand areas.

Energy efficiency

Leaks, turbulence, and imbalances increase energy consumption and compromise compliance. Properly sized and sealed ductwork lowers operational costs.

Our clean room ductwork solution

1) Engineering and BIM modeling

In BIM, we define the complete network: square/rectangular ducts for main trunks, spiroducts for branches, and fittings (connections, elbows, and reducers). We run clash detection with other disciplines and generate a numbered breakdown by zone/ISO level for installation and JIT logistics.

2) Hygienic materials and finishes

Depending on the environment, we specify epoxy-coated galvanized steel or stainless steel 304/316 for high hygiene areas. We design smooth interiors, controlled radii, and inspection openings for cleaning access.

3) Airtightness and sealing

Brida/TDF systems, EPDM-compatible gaskets, sanitary sealants, and airtight seams with shop tolerances ensured by automated machinery. This maintains differential pressure and minimizes leakage.

4) Filtration and air distribution

We integrate plenums for HEPA/ULPA filters, laminar diffusers, and strategic returns to minimize turbulence in ISO 5–7 zones. The network is balanced for stable airflow and low noise.

5) Prefabrication and clean logistics

We prefabricate with precise tolerances, pack by work front with edge protection, and deliver in JIT windows to reduce dust and handling at the job site.

6) Commissioning and validation

We support leak testing, damper adjustments, balancing, and provide documentation (packing lists and section codes) for full traceability. Coordination with your certification team is included.

Benefits for your operation

• Regulatory compliance: designed to meet ISO 14644, supporting GMP and sanitary guidelines.
• Cost savings: less rework, fewer leaks, and reduced downtime.
• Time reduction: prefabrication and JIT logistics speed up installation and validation.
• Energy efficiency: properly sized and sealed ducts reduce power consumption.
• Scalability: modular design allows for future expansion.

Use cases

Pharma and biotechnology

ISO 5–8 rooms for formulation, filling, weighing, and safe handling — with pressure control and hygienic returns.

Medical devices and microelectronics

Assembly and encapsulation areas with laminar airflow and low turbulence for strict particle control.

Food and beverage

Hygienic zones with frequent cleaning, compatible materials, and inspection access.

Healthcare (hospital)

Operating rooms, ICUs, and isolation rooms with positive/negative pressures and HEPA filtration.

Product portfolio for clean rooms

• Square and rectangular ducts with TDF/flange joints and sanitary seals.
• Spiroducts for branches and return systems.
• Fittings, elbows, and reducers with high airtightness.

Our process

1. Technical survey and ISO/GMP requirements review.
2. BIM engineering, breakdown generation, and interdisciplinary review.
3. Manufacturing with automated machinery and in-shop QA.
4. Packing by zone/ISO, JIT logistics, and reception checklist.
5. Commissioning, balancing, and validation support.

GG123 competitive advantages

• Use of BIM technology throughout the entire project cycle.
• Cost savings through reduced leakage and rework.
• Time reduction with prefabrication and sequenced deliveries.
• Automated machinery ensuring consistent tolerances.
• Comprehensive solutions: engineering, manufacturing, logistics, and support.
• Wide product range: square/rectangular ducts, spiroducts, fittings, elbows, reducers, and adapters.
• Coverage: projects in Mexico and international deliveries across Latin America.

Note: This solution adapts to the executive project, current regulations, and applicable certification criteria (ISO 14644, GMP, and local sanitary authorities).